Assay Detail
Binding
CHEMBL5258809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SOS1/GST-tagged KRAS G12C mutant (unknown origin) protein-protein interaction expressed in Escherichia coli BL21(DE3) incubated for 30 mins by NMR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.04 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519023 | — | — | 1 | 8.40 |
| CHEMBL4535474 | BAY-293 | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519023 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4535474 | BAY-293 | IC50 | = | 21.0 | nM | 7.68 |