Assay Detail
Functional
CHEMBL5259378
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Antiviral activity against SARS-CoV-2 infected in HEK293T cells expressing ACE2/TMPRSS2 assessed as reduction in virus-induced cytopathic effect measured after 48 hrs by cellular ATP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Modulation of <i>in Vitro</i> SARS-CoV-2 Infection by <i>Stephania tetrandra</i> and Its Alkaloid Constituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.35 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449782 | CEPHARANTHINE | 2.0 | 1 | 6.84 |
| CHEMBL504256 | FANGCHINOLINE | — | 1 | 6.71 |
| CHEMBL176045 | FANCHININ | — | 1 | 6.55 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL504256 | FANGCHINOLINE | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL176045 | FANCHININ | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 5100.0 | nM | 5.29 |