Assay Detail
Binding
CHEMBL5259474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain COMT using pyrocatechol as substrate by radiometric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168276 | 3,5-DINITROCATECHOL (OR-486) | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168276 | 3,5-DINITROCATECHOL (OR-486) | IC50 | = | 12.0 | nM | 7.92 |