Assay Detail
Binding
CHEMBL5259636
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Agonist activity at GPR-35 in human HT-29 cells by DMR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.63 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 9.15 |
| CHEMBL5285029 | — | — | 1 | 7.38 |
| CHEMBL5281778 | — | — | 1 | 7.30 |
| CHEMBL5288015 | — | — | 1 | 7.23 |
| CHEMBL5289040 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | EC50 | = | 0.71 | nM | 9.15 |
| CHEMBL5285029 | — | EC50 | = | 42.2 | nM | 7.38 |
| CHEMBL5281778 | — | EC50 | = | 49.5 | nM | 7.30 |
| CHEMBL5288015 | — | EC50 | = | 58.8 | nM | 7.23 |
| CHEMBL5289040 | — | EC50 | = | 80.8 | nM | 7.09 |