Assay Detail
Functional
CHEMBL5260112
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Antiviral activity against late stage HIV-1 assessed as inhibition of viral replication
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.69 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5277931 | — | — | 1 | 7.51 |
| CHEMBL5289497 | — | — | 1 | 5.57 |
| CHEMBL5275721 | — | — | 1 | 5.29 |
| CHEMBL5268275 | — | — | 1 | 5.15 |
| CHEMBL5269012 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5277931 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5289497 | — | IC50 | = | 2702.0 | nM | 5.57 |
| CHEMBL5275721 | — | IC50 | = | 5094.0 | nM | 5.29 |
| CHEMBL5268275 | — | IC50 | = | 7145.0 | nM | 5.15 |
| CHEMBL5269012 | — | IC50 | = | 12000.0 | nM | 4.92 |