Assay Detail
Functional
CHEMBL5260128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in U46619-induced preconstricted rat endothelium-intact main mesenteric artery assessed as relaxation response
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.86 | 6.70 |
| pEC50 | 15 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282156 | — | — | 2 | 6.70 |
| CHEMBL529210 | — | — | 2 | 5.80 |
| CHEMBL5284946 | — | — | 2 | 5.72 |
| CHEMBL71358 | SESALIN | — | 2 | 5.67 |
| CHEMBL5277849 | — | — | 2 | - |
| CHEMBL5281694 | — | — | 2 | - |
| CHEMBL5266969 | — | — | 2 | - |
| CHEMBL5271449 | — | — | 2 | - |
| CHEMBL5278367 | — | — | 2 | - |
| CHEMBL5278690 | — | — | 2 | - |
| CHEMBL5283500 | — | — | 2 | - |
| CHEMBL5278534 | — | — | 2 | - |
| CHEMBL5277374 | — | — | 2 | - |
| CHEMBL5272618 | — | — | 2 | - |
| CHEMBL5288862 | — | — | 2 | - |
| CHEMBL5291265 | — | — | 2 | - |
| CHEMBL5267808 | — | — | 2 | - |
| CHEMBL5279949 | — | — | 2 | - |
| CHEMBL5279732 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282156 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL529210 | — | EC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL529210 | — | EC50 | = | 1577.61 | nM | 5.80 |
| CHEMBL5284946 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5284946 | — | EC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL71358 | SESALIN | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL71358 | SESALIN | EC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL5278534 | — | pEC50 | - | — | - | |
| CHEMBL5281694 | — | pEC50 | - | — | - | |
| CHEMBL5283500 | — | EC50 | - | — | - | |
| CHEMBL5283500 | — | pEC50 | - | — | - | |
| CHEMBL5278690 | — | EC50 | - | — | - | |
| CHEMBL5278690 | — | pEC50 | - | — | - | |
| CHEMBL5278367 | — | EC50 | - | — | - | |
| CHEMBL5278367 | — | pEC50 | - | — | - | |
| CHEMBL5271449 | — | EC50 | - | — | - | |
| CHEMBL5271449 | — | pEC50 | - | — | - | |
| CHEMBL5282156 | — | EC50 | - | — | - | |
| CHEMBL5277849 | — | pEC50 | - | — | - | |
| CHEMBL5266969 | — | EC50 | - | — | - | |
| CHEMBL5266969 | — | pEC50 | - | — | - | |
| CHEMBL5281694 | — | EC50 | - | — | - | |
| CHEMBL5277849 | — | EC50 | - | — | - | |
| CHEMBL5277374 | — | pEC50 | - | — | - | |
| CHEMBL5277374 | — | EC50 | - | — | - | |
| CHEMBL5272618 | — | pEC50 | - | — | - | |
| CHEMBL5272618 | — | EC50 | - | — | - | |
| CHEMBL5288862 | — | pEC50 | - | — | - | |
| CHEMBL5288862 | — | EC50 | - | — | - | |
| CHEMBL5291265 | — | pEC50 | - | — | - | |
| CHEMBL5291265 | — | EC50 | - | — | - | |
| CHEMBL5267808 | — | pEC50 | - | — | - | |
| CHEMBL5267808 | — | EC50 | - | — | - | |
| CHEMBL5279949 | — | pEC50 | - | — | - | |
| CHEMBL5279949 | — | EC50 | - | — | - | |
| CHEMBL5279732 | — | pEC50 | - | — | - | |
| CHEMBL5279732 | — | EC50 | - | — | - | |
| CHEMBL5278534 | — | EC50 | - | — | - |