Assay Detail
Binding
CHEMBL5260167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Wee1 (214 to end residues) incubated for 1 hr in presence of tracer 178 by fluorescence based assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.15 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 7.96 |
| CHEMBL5280543 | — | — | 1 | 7.75 |
| CHEMBL5283522 | — | — | 1 | 7.72 |
| CHEMBL5268364 | — | — | 1 | 7.68 |
| CHEMBL5282089 | — | — | 1 | 7.64 |
| CHEMBL5270868 | — | — | 1 | 7.64 |
| CHEMBL5269331 | — | — | 1 | 7.46 |
| CHEMBL5286676 | — | — | 1 | 7.44 |
| CHEMBL5280507 | — | — | 1 | 7.42 |
| CHEMBL5274135 | — | — | 1 | 7.40 |
| CHEMBL5283512 | — | — | 1 | 7.39 |
| CHEMBL5288846 | — | — | 1 | 7.37 |
| CHEMBL5269748 | — | — | 1 | 7.33 |
| CHEMBL5285904 | — | — | 1 | 7.32 |
| CHEMBL5284507 | — | — | 1 | 7.28 |
| CHEMBL5267336 | — | — | 1 | 7.28 |
| CHEMBL5270289 | — | — | 1 | 7.26 |
| CHEMBL5274786 | — | — | 1 | 7.24 |
| CHEMBL5266280 | — | — | 1 | 7.19 |
| CHEMBL5287491 | — | — | 1 | 7.16 |
| CHEMBL5270087 | — | — | 1 | 7.14 |
| CHEMBL5289322 | — | — | 1 | 7.11 |
| CHEMBL5286762 | — | — | 1 | 7.11 |
| CHEMBL5281501 | — | — | 1 | 7.11 |
| CHEMBL5291088 | — | — | 1 | 7.10 |
| CHEMBL5281848 | — | — | 1 | 7.07 |
| CHEMBL5288723 | — | — | 1 | 7.05 |
| CHEMBL5276578 | — | — | 1 | 7.03 |
| CHEMBL5288299 | — | — | 1 | 7.02 |
| CHEMBL5270629 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5280543 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5283522 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5268364 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5282089 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5270868 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5269331 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5286676 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5280507 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5274135 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5283512 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5288846 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5269748 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5285904 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5267336 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5284507 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5270289 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5274786 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5266280 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5287491 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5270087 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5286762 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5281501 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5289322 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5291088 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5281848 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5288723 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5276578 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5288299 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5270629 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5282488 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5265764 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5266656 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5280159 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5280408 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL5287971 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5282168 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL5277341 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5290038 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL5289334 | — | IC50 | = | 1485.0 | nM | 5.83 |