Assay Detail
Functional
CHEMBL5260459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R mutant assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.67 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 8.96 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.22 |
| CHEMBL5275642 | — | — | 1 | 6.22 |
| CHEMBL5278657 | — | — | 1 | 5.72 |
| CHEMBL5269375 | — | — | 1 | 5.48 |
| CHEMBL5285308 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3353410 | OSIMERTINIB | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5275642 | — | EC50 | = | 605.0 | nM | 6.22 |
| CHEMBL5278657 | — | EC50 | = | 1895.0 | nM | 5.72 |
| CHEMBL5269375 | — | EC50 | = | 3341.0 | nM | 5.48 |
| CHEMBL5285308 | — | EC50 | = | 3634.0 | nM | 5.44 |