Assay Detail
Functional
CHEMBL5260646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against influenza virus H3N2 infected in dog MDCK cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.30 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.40 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 4.78 |
| CHEMBL5271525 | — | — | 1 | 4.29 |
| CHEMBL5274445 | — | — | 1 | - |
| CHEMBL5286680 | — | — | 1 | - |
| CHEMBL5287724 | — | — | 1 | - |
| CHEMBL5266539 | — | — | 1 | - |
| CHEMBL5274153 | — | — | 1 | - |
| CHEMBL5284601 | — | — | 1 | - |
| CHEMBL5273678 | — | — | 1 | - |
| CHEMBL5289851 | — | — | 1 | - |
| CHEMBL5276739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL5271525 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5274445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5286680 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5287724 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5266539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5274153 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5284601 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5273678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5289851 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5276739 | — | EC50 | > | 100000.0 | nM | - |