Assay Detail
Functional
CHEMBL5260648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against RSV infected in human HEL 299 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Respiratory syncytial virus |
| Cell Type | HEL 299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Respiratory syncytial virus (CHEMBL612679) ↗| Type | ORGANISM |
| Organism | Respiratory syncytial virus |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.88 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 7.52 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.97 |
| CHEMBL5276739 | — | — | 1 | 4.36 |
| CHEMBL5274153 | — | — | 1 | 4.19 |
| CHEMBL5271525 | — | — | 1 | 4.13 |
| CHEMBL5273678 | — | — | 1 | 4.13 |
| CHEMBL5274445 | — | — | 1 | - |
| CHEMBL5286680 | — | — | 1 | - |
| CHEMBL5287724 | — | — | 1 | - |
| CHEMBL5266539 | — | — | 1 | - |
| CHEMBL5284601 | — | — | 1 | - |
| CHEMBL5289851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5276739 | — | EC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL5274153 | — | EC50 | = | 64100.0 | nM | 4.19 |
| CHEMBL5271525 | — | EC50 | = | 73500.0 | nM | 4.13 |
| CHEMBL5273678 | — | EC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL5274445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5286680 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5287724 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5266539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5284601 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5289851 | — | EC50 | > | 100000.0 | nM | - |