Assay Detail
Functional
CHEMBL5260658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.88 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.89 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.84 |
| CHEMBL5284601 | — | — | 1 | 5.77 |
| CHEMBL5276739 | — | — | 1 | 5.70 |
| CHEMBL5266539 | — | — | 1 | 4.99 |
| CHEMBL5287724 | — | — | 1 | 4.52 |
| CHEMBL5271525 | — | — | 1 | 4.27 |
| CHEMBL5273678 | — | — | 1 | 4.18 |
| CHEMBL5286680 | — | — | 1 | 4.16 |
| CHEMBL5274153 | — | — | 1 | 4.14 |
| CHEMBL5289851 | — | — | 1 | 4.09 |
| CHEMBL5274445 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5284601 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5276739 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5266539 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5287724 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL5271525 | — | IC50 | = | 54200.0 | nM | 4.27 |
| CHEMBL5273678 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL5286680 | — | IC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL5274153 | — | IC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL5289851 | — | IC50 | = | 80600.0 | nM | 4.09 |
| CHEMBL5274445 | — | IC50 | = | 99300.0 | nM | 4.00 |