Assay Detail
Binding
CHEMBL5261312
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Binding affinity to C-terminal amidated influenza A virus A/Udorn/72 (H3N2) M2 transmembrane domain (22 to 46 residues) in DPC micelles at pH 8 assessed as dissociation constant by ITC analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.36 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277543 | — | — | 1 | 6.89 |
| CHEMBL1235691 | — | — | 1 | 6.50 |
| CHEMBL3392935 | — | — | 1 | 6.47 |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 6.29 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277543 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL1235691 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL3392935 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL959 | RIMANTADINE | Kd | = | 510.0 | nM | 6.29 |
| CHEMBL660 | AMANTADINE | Kd | = | 2170.0 | nM | 5.66 |