Assay Detail
Functional
CHEMBL5263136
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Anticancer activity against human CNE-2 cells assessed as inhibition of cell growth
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CNE-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylpyrimidine coumarin derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.17 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280294 | — | — | 1 | 5.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.67 |
| CHEMBL5272341 | — | — | 1 | 5.63 |
| CHEMBL5288791 | — | — | 1 | 5.46 |
| CHEMBL5272170 | — | — | 1 | 5.37 |
| CHEMBL5272458 | — | — | 1 | 5.37 |
| CHEMBL5267879 | — | — | 1 | 4.96 |
| CHEMBL5270093 | — | — | 1 | 4.84 |
| CHEMBL5287988 | — | — | 1 | 4.79 |
| CHEMBL5289403 | — | — | 1 | 4.78 |
| CHEMBL5279003 | — | — | 1 | 4.73 |
| CHEMBL5273293 | — | — | 1 | 4.68 |
| CHEMBL5289870 | — | — | 1 | - |
| CHEMBL5283808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280294 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5272341 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL5288791 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL5272170 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL5272458 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5267879 | — | IC50 | = | 11070.0 | nM | 4.96 |
| CHEMBL5270093 | — | IC50 | = | 14580.0 | nM | 4.84 |
| CHEMBL5287988 | — | IC50 | = | 16250.0 | nM | 4.79 |
| CHEMBL5289403 | — | IC50 | = | 16570.0 | nM | 4.78 |
| CHEMBL5279003 | — | IC50 | = | 18640.0 | nM | 4.73 |
| CHEMBL5273293 | — | IC50 | = | 20640.0 | nM | 4.68 |
| CHEMBL5289870 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5283808 | — | IC50 | > | 100000.0 | nM | - |