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Assay Detail

CHEMBL5263441

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human liver FBPase by spectrophotometric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Liver
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fructose-1,6-bisphosphatase 1 (CHEMBL3975)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Kaur R, Dahiya L, Kumar M.
Eur J Med Chem (2017) 141 : 473 -505
PubMed 29055870 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.16 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5271686 1 7.96
CHEMBL501816 1 7.85
CHEMBL5278857 1 7.47
CHEMBL5272081 1 7.22
CHEMBL5277487 1 6.85
CHEMBL5286087 1 6.43
CHEMBL483354 1 6.16
CHEMBL5269366 1 5.80
CHEMBL1230892 1 5.70
CHEMBL1097227 1 5.22
CHEMBL5291240 1 4.64
CHEMBL5269870 1 4.44
CHEMBL5289074 1 4.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5271686 IC50 = 11.0 nM 7.96
CHEMBL501816 IC50 = 14.0 nM 7.85
CHEMBL5278857 IC50 = 34.0 nM 7.47
CHEMBL5272081 IC50 = 60.0 nM 7.22
CHEMBL5277487 IC50 = 140.0 nM 6.85
CHEMBL5286087 IC50 = 370.0 nM 6.43
CHEMBL483354 IC50 = 700.0 nM 6.16
CHEMBL5269366 IC50 = 1600.0 nM 5.80
CHEMBL1230892 IC50 = 2000.0 nM 5.70
CHEMBL1097227 IC50 = 6000.0 nM 5.22
CHEMBL5291240 IC50 = 23000.0 nM 4.64
CHEMBL5269870 IC50 = 36000.0 nM 4.44
CHEMBL5289074 IC50 = 51200.0 nM 4.29