Assay Detail
Binding
CHEMBL5263443
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Inhibition of human liver FBPase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.20 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784789 | — | — | 1 | 7.51 |
| CHEMBL3393956 | — | — | 1 | 7.00 |
| CHEMBL65250 | — | — | 1 | 6.60 |
| CHEMBL301018 | — | — | 1 | 6.54 |
| CHEMBL3127628 | — | — | 1 | 6.00 |
| CHEMBL64950 | — | — | 1 | 5.80 |
| CHEMBL1521269 | — | — | 1 | 5.35 |
| CHEMBL3287951 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784789 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3393956 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL65250 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL301018 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3127628 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL64950 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1521269 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL3287951 | — | IC50 | = | 15450.0 | nM | 4.81 |