Assay Detail
Binding
CHEMBL5263445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human liver FBPase expressed in Escherichia coli
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495498 | MB-05032 | 2.0 | 1 | 7.80 |
| CHEMBL570790 | — | — | 1 | 7.05 |
| CHEMBL482735 | — | — | 1 | - |
| CHEMBL507312 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495498 | MB-05032 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL570790 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL482735 | — | IC50 | = | 800000.0 | nM | - |
| CHEMBL507312 | — | IC50 | = | 700000.0 | nM | - |