Assay Detail
Binding
CHEMBL5263447
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Inhibition of recombinant C-terminal His-tagged human liver FBPase expressed in Escherichia coli BL21 (DE3)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.54 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205792 | — | — | 1 | 6.24 |
| CHEMBL3127767 | — | — | 1 | 5.47 |
| CHEMBL3127629 | — | — | 1 | 5.37 |
| CHEMBL3127755 | — | — | 1 | 5.35 |
| CHEMBL3127747 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205792 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3127767 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3127629 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3127755 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3127747 | — | IC50 | = | 5400.0 | nM | 5.27 |