Assay Detail
Binding
CHEMBL5263770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S]-TBPS GABAA receptor in Wistar rat brain membrane incubated for 60 mins by competitive binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Breakthroughs in neuroactive steroid drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.30 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 7.10 |
| CHEMBL5266289 | — | — | 1 | 6.59 |
| CHEMBL5268883 | — | — | 1 | 6.20 |
| CHEMBL5284331 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5266289 | — | IC50 | = | 255.3 | nM | 6.59 |
| CHEMBL5268883 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5284331 | — | IC50 | = | 5000.0 | nM | 5.30 |