Assay Detail
Functional
CHEMBL5264781
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Cytotoxicity against human SK-MEL3 cells assessed as cell growth inhibition upto 10 uM measured after 48 hrs by Caspase-Glo reagent based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.83 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280568 | — | — | 1 | 8.89 |
| CHEMBL5278653 | — | — | 1 | 8.38 |
| CHEMBL5283715 | — | — | 1 | 8.25 |
| CHEMBL5267447 | — | — | 1 | 7.96 |
| CHEMBL1495092 | — | — | 1 | 7.92 |
| CHEMBL5268658 | — | — | 1 | 7.54 |
| CHEMBL5286823 | — | — | 1 | 7.51 |
| CHEMBL5275420 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280568 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5278653 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5283715 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5267447 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1495092 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5268658 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5286823 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5275420 | — | EC50 | = | 684.0 | nM | 6.17 |