Assay Detail
Functional
CHEMBL5264795
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Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by Caspase-Glo reagent based assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 7.82 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284290 | — | — | 1 | 8.96 |
| CHEMBL5280568 | — | — | 1 | 8.80 |
| CHEMBL5279968 | — | — | 1 | 8.66 |
| CHEMBL5273714 | — | — | 1 | 8.55 |
| CHEMBL5268675 | — | — | 1 | 8.48 |
| CHEMBL4247714 | — | — | 1 | 8.42 |
| CHEMBL5280347 | — | — | 1 | 8.35 |
| CHEMBL5283715 | — | — | 1 | 8.35 |
| CHEMBL5278653 | — | — | 1 | 8.31 |
| CHEMBL1495092 | — | — | 1 | 8.16 |
| CHEMBL5275174 | — | — | 1 | 8.15 |
| CHEMBL5278202 | — | — | 1 | 8.11 |
| CHEMBL5278925 | — | — | 1 | 8.06 |
| CHEMBL5289581 | — | — | 1 | 8.06 |
| CHEMBL5290538 | — | — | 1 | 7.89 |
| CHEMBL5274843 | — | — | 1 | 7.89 |
| CHEMBL5283329 | — | — | 1 | 7.80 |
| CHEMBL5289617 | — | — | 1 | 7.68 |
| CHEMBL5290843 | — | — | 1 | 7.66 |
| CHEMBL5286823 | — | — | 1 | 7.62 |
| CHEMBL5268658 | — | — | 1 | 7.48 |
| CHEMBL5267447 | — | — | 1 | 7.44 |
| CHEMBL5279566 | — | — | 1 | 7.19 |
| CHEMBL5278913 | — | — | 1 | 7.19 |
| CHEMBL5287653 | — | — | 1 | 7.15 |
| CHEMBL5290586 | — | — | 1 | 6.89 |
| CHEMBL5283109 | — | — | 1 | 6.62 |
| CHEMBL5275420 | — | — | 1 | 6.51 |
| CHEMBL5280872 | — | — | 1 | 6.39 |
| CHEMBL5268188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284290 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5280568 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5279968 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5273714 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5268675 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4247714 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5280347 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5283715 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5278653 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1495092 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5275174 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5278202 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5278925 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5289581 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5274843 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5290538 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5283329 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5289617 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5290843 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5286823 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5268658 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5267447 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5278913 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5279566 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5287653 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5290586 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5283109 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5275420 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5280872 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5269934 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5273160 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5280390 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5279938 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5278773 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL340785 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5268144 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5281139 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5267096 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5269656 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5284388 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5273764 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5268188 | — | EC50 | > | 1000.0 | nM | - |