Assay Detail
Binding
CHEMBL5264797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal His-GST-tagged recombinant PDE3A (669-end residues) using fluorescent labelled cAMP as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283715 | — | — | 1 | 8.10 |
| CHEMBL5286823 | — | — | 1 | 8.10 |
| CHEMBL5280568 | — | — | 1 | 8.00 |
| CHEMBL340785 | — | — | 1 | 7.62 |
| CHEMBL1495092 | — | — | 1 | 7.60 |
| CHEMBL5267447 | — | — | 1 | 6.92 |
| CHEMBL5275420 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283715 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5286823 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5280568 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340785 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1495092 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5267447 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5275420 | — | IC50 | = | 2000.0 | nM | 5.70 |