Assay Detail
Functional
CHEMBL5265052
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Antiproliferative activity against multidrug resistant human NCI-H69AR assessed as inhibition of cell proliferation by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H69AR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current scenario of indole derivatives with potential anti-drug-resistant cancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.94 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.24 |
| CHEMBL5267163 | — | — | 1 | 4.80 |
| CHEMBL5282059 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5267163 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5282059 | — | IC50 | = | 16600.0 | nM | 4.78 |