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Target Snapshot

CHEMBL5209893 Target Snapshot

H69AR · CELL-LINE · Homo sapiens

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99Compounds
66Assays
6Approved Drugs
103.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H69AR as ChEMBL target CHEMBL5209893. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H69AR
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5209893
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H69AR still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameH69AR
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH69AR
UniProt AccessionN/A

H69AR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as H69AR.

Review nameH69AR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

6
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50102.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL159 8.8 IC50 1.6 Approved
CHEMBL374481 8.66 IC50 2.2 Preclinical
CHEMBL374683 8.6 IC50 2.5 Preclinical
CHEMBL428647 8.6 IC50 2.5 Approved
CHEMBL67 8.6 IC50 2.5 Preclinical
CHEMBL374257 8.59 IC50 2.6 Preclinical
CHEMBL5202359 8.25 IC50 5.57 Preclinical
CHEMBL307794 8.2 IC50 6.29 Preclinical
CHEMBL301226 7.22 IC50 60.0 Preclinical
CHEMBL1688855 7.04 IC50 91.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
10
5.5
2
6.0
5
6.5
2
7.0
0
7.5
2
8.0
6
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

66
Total Assays
64
Tested Compounds
1
Assay Types
Functional — 66 assays, 64 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 66 64 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine