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Assay Detail

CHEMBL5265197

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Binding
Inhibition of human CA1
ChEMBL ↗
70
Total Activities
57
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advancements in the development of bioactive pyrazoline derivatives.
Nehra B, Rulhania S, Jaswal S, Kumar B, Singh G, Monga V.
Eur J Med Chem (2020) 205 : 112666 -112666
PubMed 32795767 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 61 7.26 8.48
IC50 9 8.23 8.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4872387 — — 2 8.48
CHEMBL4847613 — — 2 8.48
CHEMBL4857592 — — 2 8.48
CHEMBL4849196 — — 2 8.48
CHEMBL4869398 — — 2 8.48
CHEMBL4847624 — — 2 8.48
CHEMBL4876038 — — 2 8.48
CHEMBL4864555 — — 2 8.48
CHEMBL5204253 — — 1 8.29
CHEMBL5177553 — — 1 8.29
CHEMBL5199726 — — 1 8.29
CHEMBL471655 — — 1 8.29
CHEMBL589993 — — 1 8.29
CHEMBL471438 — — 1 8.29
CHEMBL5182933 — — 1 8.29
CHEMBL5177252 — — 1 8.29
CHEMBL5175856 — — 1 8.29
CHEMBL593207 — — 1 8.29
CHEMBL5271374 — — 1 7.58
CHEMBL5272136 — — 1 7.58
CHEMBL5279227 — — 1 7.58
CHEMBL5269093 — — 1 7.58
CHEMBL5280569 — — 1 7.58
CHEMBL5289839 — — 1 7.58
CHEMBL5273842 — — 1 7.06
CHEMBL5290155 — — 1 7.06
CHEMBL5286421 — — 1 7.06
CHEMBL5291363 — — 1 7.06
CHEMBL5267702 — — 1 7.06
CHEMBL5280216 — — 1 7.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4872387 — Ki = 3.3 nM 8.48
CHEMBL4847613 — Ki = 3.3 nM 8.48
CHEMBL4857592 — Ki = 3.3 nM 8.48
CHEMBL4849196 — Ki = 3.3 nM 8.48
CHEMBL4869398 — Ki = 3.3 nM 8.48
CHEMBL4847624 — Ki = 3.3 nM 8.48
CHEMBL4876038 — Ki = 3.3 nM 8.48
CHEMBL4864555 — Ki = 3.3 nM 8.48
CHEMBL4847624 — IC50 = 3.77 nM 8.42
CHEMBL4864555 — IC50 = 3.77 nM 8.42
CHEMBL4872387 — IC50 = 3.77 nM 8.42
CHEMBL4857592 — IC50 = 3.77 nM 8.42
CHEMBL4849196 — IC50 = 3.77 nM 8.42
CHEMBL4876038 — IC50 = 3.77 nM 8.42
CHEMBL4869398 — IC50 = 3.77 nM 8.42
CHEMBL4847613 — IC50 = 3.77 nM 8.42
CHEMBL5177553 — Ki = 5.13 nM 8.29
CHEMBL5199726 — Ki = 5.13 nM 8.29
CHEMBL5204253 — Ki = 5.13 nM 8.29
CHEMBL5175856 — Ki = 5.13 nM 8.29
CHEMBL5177252 — Ki = 5.13 nM 8.29
CHEMBL471438 — Ki = 5.13 nM 8.29
CHEMBL593207 — Ki = 5.13 nM 8.29
CHEMBL589993 — Ki = 5.13 nM 8.29
CHEMBL471655 — Ki = 5.13 nM 8.29
CHEMBL5182933 — Ki = 5.13 nM 8.29
CHEMBL5289839 — Ki = 26.5 nM 7.58
CHEMBL5272136 — Ki = 26.5 nM 7.58
CHEMBL5280569 — Ki = 26.5 nM 7.58
CHEMBL5269093 — Ki = 26.5 nM 7.58
CHEMBL5271374 — Ki = 26.5 nM 7.58
CHEMBL5279227 — Ki = 26.5 nM 7.58
CHEMBL5274534 — Ki = 87.8 nM 7.06
CHEMBL5285856 — Ki = 87.8 nM 7.06
CHEMBL5275956 — Ki = 87.8 nM 7.06
CHEMBL5290244 — Ki = 87.8 nM 7.06
CHEMBL5273725 — Ki = 87.8 nM 7.06
CHEMBL5287974 — Ki = 87.8 nM 7.06
CHEMBL5280216 — Ki = 87.8 nM 7.06
CHEMBL5267702 — Ki = 87.8 nM 7.06
CHEMBL5291363 — Ki = 87.8 nM 7.06
CHEMBL5286421 — Ki = 87.8 nM 7.06
CHEMBL5290155 — Ki = 87.8 nM 7.06
CHEMBL5279517 — Ki = 87.8 nM 7.06
CHEMBL5273842 — Ki = 87.8 nM 7.06
CHEMBL20 ACETAZOLAMIDE Ki = 182.0 nM 6.74
CHEMBL20 ACETAZOLAMIDE IC50 = 197.0 nM 6.71
CHEMBL5282415 — Ki = 232.16 nM 6.63
CHEMBL5273236 — Ki = 232.16 nM 6.63
CHEMBL5283590 — Ki = 232.16 nM 6.63