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Assay Detail

CHEMBL5265203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of AChE (unknown origin)
23
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advancements in the development of bioactive pyrazoline derivatives.
Nehra B, Rulhania S, Jaswal S, Kumar B, Singh G, Monga V.
Eur J Med Chem (2020) 205 : 112666 -112666
PubMed 32795767 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.49 8.20
Ki 9 8.39 8.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876038 2 8.48
CHEMBL4847624 2 8.48
CHEMBL4869398 2 8.48
CHEMBL4849196 2 8.48
CHEMBL4857592 2 8.48
CHEMBL4847613 2 8.48
CHEMBL4872387 2 8.48
CHEMBL4864555 2 8.48
CHEMBL95 TACRINE 4.0 2 7.64
CHEMBL2238280 1 6.89
CHEMBL2236142 1 6.82
CHEMBL2238282 1 6.80
CHEMBL2236140 1 6.70
CHEMBL278020 NEOSTIGMINE 4.0 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4872387 Ki = 3.28 nM 8.48
CHEMBL4847613 Ki = 3.28 nM 8.48
CHEMBL4857592 Ki = 3.28 nM 8.48
CHEMBL4849196 Ki = 3.28 nM 8.48
CHEMBL4869398 Ki = 3.28 nM 8.48
CHEMBL4847624 Ki = 3.28 nM 8.48
CHEMBL4876038 Ki = 3.28 nM 8.48
CHEMBL4864555 Ki = 3.28 nM 8.48
CHEMBL4847613 IC50 = 6.36 nM 8.20
CHEMBL4847624 IC50 = 6.36 nM 8.20
CHEMBL4869398 IC50 = 6.36 nM 8.20
CHEMBL4849196 IC50 = 6.36 nM 8.20
CHEMBL4857592 IC50 = 6.36 nM 8.20
CHEMBL4872387 IC50 = 6.36 nM 8.20
CHEMBL4864555 IC50 = 6.36 nM 8.20
CHEMBL4876038 IC50 = 6.36 nM 8.20
CHEMBL95 TACRINE Ki = 22.99 nM 7.64
CHEMBL95 TACRINE IC50 = 43.21 nM 7.36
CHEMBL2238280 IC50 = 130.0 nM 6.89
CHEMBL2236142 IC50 = 150.0 nM 6.82
CHEMBL2238282 IC50 = 160.0 nM 6.80
CHEMBL2236140 IC50 = 200.0 nM 6.70
CHEMBL278020 NEOSTIGMINE IC50 = 22200.0 nM 4.65