Assay Detail
Binding
CHEMBL5304355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE9A)
2
Total Activities
2
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL3535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe BAY-7081
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.82 | 7.82 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | SPA assay system from Perkin Elmer |
| Assay publication | Assay publication | - | — | PMID: 36475653 |
| Target protein length | Target protein length | - | — | full-length human |
| Target protein type | Target protein type | - | — | recombinant protein expressed in Sf9 insect cells |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5306577 | — | — | 1 | 7.82 |
| CHEMBL5308250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5306577 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5308250 | — | IC50 | > | 10000.0 | nM | - |