Assay Detail
Binding
CHEMBL5316893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to mouse mu opioid receptor expressed in CHO cell membrane assessed as inhibition constant incubated for 1.5 hrs by competitive radioligand binding assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 9.09 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399596 | — | — | 1 | 9.64 |
| CHEMBL4595328 | — | — | 1 | 9.64 |
| CHEMBL5423403 | — | — | 1 | 9.60 |
| CHEMBL5427274 | — | — | 1 | 9.57 |
| CHEMBL5432174 | — | — | 1 | 9.51 |
| CHEMBL5417637 | — | — | 1 | 9.46 |
| CHEMBL5416619 | — | — | 1 | 9.42 |
| CHEMBL5432205 | — | — | 1 | 9.37 |
| CHEMBL5432317 | — | — | 1 | 9.34 |
| CHEMBL5426766 | — | — | 1 | 9.32 |
| CHEMBL5420457 | — | — | 1 | 9.27 |
| CHEMBL5432371 | — | — | 1 | 9.23 |
| CHEMBL5440937 | — | — | 1 | 9.21 |
| CHEMBL5431128 | — | — | 1 | 9.20 |
| CHEMBL5415668 | — | — | 1 | 9.19 |
| CHEMBL5434721 | — | — | 1 | 9.16 |
| CHEMBL5411900 | — | — | 1 | 9.16 |
| CHEMBL5401578 | — | — | 1 | 9.15 |
| CHEMBL5438077 | — | — | 1 | 9.14 |
| CHEMBL5427896 | — | — | 1 | 9.06 |
| CHEMBL5425838 | — | — | 1 | 9.06 |
| CHEMBL5405519 | — | — | 1 | 9.05 |
| CHEMBL5405800 | — | — | 1 | 9.03 |
| CHEMBL5425108 | — | — | 1 | 9.01 |
| CHEMBL5417814 | — | — | 1 | 8.97 |
| CHEMBL5434911 | — | — | 1 | 8.84 |
| CHEMBL5398970 | — | — | 1 | 8.84 |
| CHEMBL5396504 | — | — | 1 | 8.68 |
| CHEMBL5429587 | — | — | 1 | 8.62 |
| CHEMBL5424438 | — | — | 1 | 8.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399596 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4595328 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL5423403 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL5427274 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL5432174 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL5417637 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL5416619 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL5432205 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL5432317 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL5426766 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL5420457 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL5432371 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL5440937 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL5431128 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL5415668 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL5434721 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL5411900 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL5401578 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5438077 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL5427896 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL5425838 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL5405519 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL5405800 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL5425108 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL5417814 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL5398970 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL5434911 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL5396504 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL5429587 | — | Ki | = | 2.37 | nM | 8.62 |
| CHEMBL5424438 | — | Ki | = | 2.45 | nM | 8.61 |
| CHEMBL5424642 | — | Ki | = | 2.66 | nM | 8.57 |
| CHEMBL5403273 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL5419838 | — | Ki | = | 3.26 | nM | 8.49 |
| CHEMBL5406491 | — | Ki | = | 5.57 | nM | 8.25 |
| CHEMBL5434134 | — | Ki | > | 50.0 | nM | - |