Assay Detail
Functional
CHEMBL5317648
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Antiproliferative activity against human Androgen-resistant 22Rv1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Androgen-resistant 22Rv1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Physachenolide C is a Potent, Selective BET Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL3605565 | — | — | 1 | 7.52 |
| CHEMBL1097107 | WITHANOLIDE E | — | 1 | 7.16 |
| CHEMBL3605564 | — | — | 1 | 7.16 |
| CHEMBL4075419 | — | — | 1 | 6.75 |
| CHEMBL4203685 | — | — | 1 | 6.68 |
| CHEMBL1957266 | — | — | 1 | 6.64 |
| CHEMBL5438438 | — | — | 1 | 5.95 |
| CHEMBL5416439 | — | — | 1 | 5.83 |
| CHEMBL5401408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3605565 | — | EC50 | = | 30.3 | nM | 7.52 |
| CHEMBL1097107 | WITHANOLIDE E | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3605564 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4075419 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4203685 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1957266 | — | EC50 | = | 230.5 | nM | 6.64 |
| CHEMBL5438438 | — | EC50 | = | 1131.6 | nM | 5.95 |
| CHEMBL5416439 | — | EC50 | = | 1494.2 | nM | 5.83 |
| CHEMBL5401408 | — | EC50 | > | 2000.0 | nM | - |