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Compound Detail

CHEMBL5438438

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CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1C[C@H](C)[C@H](C)C(=O)O1

Basic Information

ChEMBL ID CHEMBL5438438
Phase Preclinical
Structure Type MOL
InChI Key XPUHRVWZXYYOML-VMGDNSSASA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

546.7
MW (Da)
2.23
ALogP
9
HBA
3
HBD
142.9
PSA (Ų)
0.36
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H42O9
MW 546.66
Aromatic Rings 0
Heavy Atoms 39
NP-Likeness 3.42

Activity Summary

EC50 3 meas. best 6.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
PC-3
CHEMBL390
EC50 6.05 6.05 899.0 1
LNCaP
CHEMBL612518
EC50 5.98 5.98 1052.3 1
Unchecked
CHEMBL612545
EC50 5.95 5.95 1131.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine