Assay Detail
Functional
CHEMBL5317650
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Antiproliferative activity against androgen-insensitive human PC-3 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Physachenolide C is a Potent, Selective BET Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.26 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605565 | — | — | 1 | 7.20 |
| CHEMBL3605564 | — | — | 1 | 6.89 |
| CHEMBL4074906 | — | — | 1 | 6.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.47 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 6.39 |
| CHEMBL4075419 | — | — | 1 | 6.37 |
| CHEMBL5416439 | — | — | 1 | 6.07 |
| CHEMBL5438438 | — | — | 1 | 6.05 |
| CHEMBL4082632 | — | — | 1 | 5.96 |
| CHEMBL3605566 | — | — | 1 | 5.92 |
| CHEMBL5412959 | — | — | 1 | 5.54 |
| CHEMBL3605560 | — | — | 1 | 5.51 |
| CHEMBL5401408 | — | — | 1 | - |
| CHEMBL1957266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605565 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3605564 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4074906 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL517080 | WITHAFERIN A | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4075419 | — | EC50 | = | 424.8 | nM | 6.37 |
| CHEMBL5416439 | — | EC50 | = | 844.0 | nM | 6.07 |
| CHEMBL5438438 | — | EC50 | = | 899.0 | nM | 6.05 |
| CHEMBL4082632 | — | EC50 | = | 1098.0 | nM | 5.96 |
| CHEMBL3605566 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5412959 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3605560 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5401408 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL1957266 | — | EC50 | > | 2000.0 | nM | - |