Assay Detail
Binding
CHEMBL5317690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of europium-labeled PD-1/biotinylated PD-L1 interaction (unknown origin) preincubated for 15 mins with PD-L1 followed by PD-1 addition and measured after 90 mins by TR-FRET assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.21 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398323 | — | — | 1 | 8.21 |
| CHEMBL5419371 | — | — | 1 | 7.81 |
| CHEMBL4089730 | — | — | 1 | 7.77 |
| CHEMBL5398538 | — | — | 1 | 7.77 |
| CHEMBL5419794 | — | — | 1 | 7.45 |
| CHEMBL5426890 | — | — | 1 | 7.33 |
| CHEMBL5393988 | — | — | 1 | 6.86 |
| CHEMBL5408902 | — | — | 1 | 6.81 |
| CHEMBL5440260 | — | — | 1 | 6.60 |
| CHEMBL5429381 | — | — | 1 | 6.53 |
| CHEMBL5421369 | — | — | 1 | 6.47 |
| CHEMBL5426582 | — | — | 1 | 6.40 |
| CHEMBL5414868 | — | — | 1 | 6.23 |
| CHEMBL5410266 | — | — | 1 | 6.17 |
| CHEMBL5423459 | — | — | 1 | 6.13 |
| CHEMBL5437071 | — | — | 1 | 6.04 |
| CHEMBL5407423 | — | — | 1 | 6.04 |
| CHEMBL5404396 | — | — | 1 | 6.01 |
| CHEMBL5437621 | — | — | 1 | 5.97 |
| CHEMBL5401111 | — | — | 1 | 5.93 |
| CHEMBL5410428 | — | — | 1 | 5.85 |
| CHEMBL5431490 | — | — | 1 | 5.72 |
| CHEMBL5423192 | — | — | 1 | 5.71 |
| CHEMBL5420473 | — | — | 1 | 5.67 |
| CHEMBL5440211 | — | — | 1 | 5.66 |
| CHEMBL5425609 | — | — | 1 | 5.62 |
| CHEMBL5424023 | — | — | 1 | 5.62 |
| CHEMBL5404934 | — | — | 1 | 5.60 |
| CHEMBL5423020 | — | — | 1 | 5.56 |
| CHEMBL5429408 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398323 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5419371 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5398538 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL4089730 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5419794 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL5426890 | — | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL5393988 | — | IC50 | = | 138.8 | nM | 6.86 |
| CHEMBL5408902 | — | IC50 | = | 156.2 | nM | 6.81 |
| CHEMBL5440260 | — | IC50 | = | 249.4 | nM | 6.60 |
| CHEMBL5429381 | — | IC50 | = | 296.1 | nM | 6.53 |
| CHEMBL5421369 | — | IC50 | = | 342.3 | nM | 6.47 |
| CHEMBL5426582 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL5414868 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5410266 | — | IC50 | = | 683.2 | nM | 6.17 |
| CHEMBL5423459 | — | IC50 | = | 744.9 | nM | 6.13 |
| CHEMBL5437071 | — | IC50 | = | 917.2 | nM | 6.04 |
| CHEMBL5407423 | — | IC50 | = | 912.1 | nM | 6.04 |
| CHEMBL5404396 | — | IC50 | = | 968.3 | nM | 6.01 |
| CHEMBL5437621 | — | IC50 | = | 1059.0 | nM | 5.97 |
| CHEMBL5401111 | — | IC50 | = | 1175.0 | nM | 5.93 |
| CHEMBL5410428 | — | IC50 | = | 1423.0 | nM | 5.85 |
| CHEMBL5431490 | — | IC50 | = | 1885.0 | nM | 5.72 |
| CHEMBL5423192 | — | IC50 | = | 1952.0 | nM | 5.71 |
| CHEMBL5420473 | — | IC50 | = | 2113.0 | nM | 5.67 |
| CHEMBL5440211 | — | IC50 | = | 2208.0 | nM | 5.66 |
| CHEMBL5425609 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5424023 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5404934 | — | IC50 | = | 2519.0 | nM | 5.60 |
| CHEMBL5423020 | — | IC50 | = | 2765.0 | nM | 5.56 |
| CHEMBL5429408 | — | IC50 | = | 3668.0 | nM | 5.44 |
| CHEMBL5407051 | — | IC50 | = | 3838.0 | nM | 5.42 |
| CHEMBL5416067 | — | IC50 | = | 4629.0 | nM | 5.33 |
| CHEMBL5435306 | — | IC50 | = | 5128.0 | nM | 5.29 |
| CHEMBL5438458 | — | IC50 | = | 5405.0 | nM | 5.27 |
| CHEMBL5414269 | — | IC50 | = | 6688.0 | nM | 5.17 |
| CHEMBL5436142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5438870 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5395885 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432996 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5429195 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5423496 | — | IC50 | > | 10000.0 | nM | - |