Assay Detail
Binding
CHEMBL5318008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 mins
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
D-3-phosphoglycerate dehydrogenase (CHEMBL2311243) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.26 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4533417 | — | — | 1 | 6.97 |
| CHEMBL4545772 | — | — | 1 | 6.79 |
| CHEMBL5415992 | — | — | 1 | 5.66 |
| CHEMBL5418330 | — | — | 1 | 5.62 |
| CHEMBL5435562 | — | — | 1 | 5.58 |
| CHEMBL5436320 | — | — | 1 | 5.55 |
| CHEMBL5440487 | — | — | 1 | 5.50 |
| CHEMBL5418314 | — | — | 1 | 5.45 |
| CHEMBL5404538 | — | — | 1 | 5.42 |
| CHEMBL5394206 | — | — | 1 | 5.32 |
| CHEMBL5412915 | — | — | 1 | 5.30 |
| CHEMBL5401773 | — | — | 1 | 5.27 |
| CHEMBL4070806 | — | — | 1 | 5.21 |
| CHEMBL5413529 | — | — | 1 | 5.21 |
| CHEMBL5409883 | — | — | 1 | 5.19 |
| CHEMBL5426021 | — | — | 1 | 5.17 |
| CHEMBL5413530 | — | — | 1 | 5.17 |
| CHEMBL5405367 | — | — | 1 | 5.15 |
| CHEMBL5422286 | — | — | 1 | 5.13 |
| CHEMBL5411304 | — | — | 1 | 5.11 |
| CHEMBL5404397 | — | — | 1 | 5.10 |
| CHEMBL5439942 | — | — | 1 | 4.96 |
| CHEMBL5403306 | — | — | 1 | 4.94 |
| CHEMBL5406447 | — | — | 1 | 4.91 |
| CHEMBL5424581 | — | — | 1 | 4.90 |
| CHEMBL5419037 | — | — | 1 | 4.89 |
| CHEMBL5404649 | — | — | 1 | 4.89 |
| CHEMBL5399957 | — | — | 1 | 4.80 |
| CHEMBL5427764 | — | — | 1 | 4.80 |
| CHEMBL5408434 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4533417 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4545772 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL5415992 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5418330 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5435562 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5436320 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5440487 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL5418314 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL5404538 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5394206 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5412915 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL5401773 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL4070806 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5413529 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL5409883 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5413530 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL5426021 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5405367 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL5422286 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL5411304 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL5404397 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL5439942 | — | IC50 | = | 10850.0 | nM | 4.96 |
| CHEMBL5403306 | — | IC50 | = | 11380.0 | nM | 4.94 |
| CHEMBL5406447 | — | IC50 | = | 12210.0 | nM | 4.91 |
| CHEMBL5424581 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5419037 | — | IC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL5404649 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5399957 | — | IC50 | = | 15690.0 | nM | 4.80 |
| CHEMBL5427764 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5408434 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5427304 | — | IC50 | = | 17840.0 | nM | 4.75 |
| CHEMBL5439263 | — | IC50 | = | 18500.0 | nM | 4.73 |