Assay Detail
Binding
CHEMBL5318271
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Inhibition of 20s immunoproteasome beta-5i subunit (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.61 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484156 | — | — | 1 | 6.52 |
| CHEMBL2346855 | — | — | 1 | 5.66 |
| CHEMBL4522536 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484156 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2346855 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4522536 | — | IC50 | = | 22800.0 | nM | 4.64 |