Assay Detail
Functional
CHEMBL5318290
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Cytotoxicity against human MM1.S cells after 72 hrs by celltitre-glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.70 |
| CHEMBL5431856 | — | — | 1 | 7.24 |
| CHEMBL4741140 | — | — | 1 | 6.90 |
| CHEMBL5441116 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5431856 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4741140 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5441116 | — | EC50 | = | 760.0 | nM | 6.12 |