Assay Detail
Functional
CHEMBL5318291
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Cytotoxicity against human RPMI-8226 cells after 72 hrs by celltitre-glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.29 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.40 |
| CHEMBL4741140 | — | — | 1 | 6.16 |
| CHEMBL5431856 | — | — | 1 | 5.78 |
| CHEMBL5441116 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4741140 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5431856 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL5441116 | — | EC50 | = | 15000.0 | nM | 4.82 |