Assay Detail
Functional
CHEMBL5318293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic cytotoxic activity against human RPMI-8226 cells after 72 hrs in presence of 0.25 uM of (S)-N5-(tert-butyl)-N1-((S)-1-(((4-fluoronaphthalen-1-yl)methyl)amino)-3-methoxy-1-oxopropan-2-yl)-2-((4-methylphenyl)sulfonamido)pentanediamide by celltitre-glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.76 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431856 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431856 | — | EC50 | = | 173.0 | nM | 6.76 |