Assay Detail
Binding
CHEMBL5318754
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Inhibition of Staphylococcus aureus DNA gyrase incubated for 30 mins by fluorescence based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.79 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854181 | — | — | 1 | 9.10 |
| CHEMBL4873935 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854181 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4873935 | — | IC50 | = | 3.3 | nM | 8.48 |