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Assay Detail

CHEMBL5318765

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Acinetobacter baumannii 1419130 full length wildtype DNA Gyrase B (residue 28 to 233) supercoiling in presence of pNO1 plasmid incubated for 30 mins by microplate reader assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Acinetobacter baumannii
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>.
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D.
J Med Chem (2023) 66 : 1380 -1425
PubMed 36634346 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 7.66 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5426748 — — 1 7.80
CHEMBL5418293 — — 1 7.80
CHEMBL5419700 — — 1 7.60
CHEMBL5416167 — — 1 7.58
CHEMBL5428079 — — 1 7.54
CHEMBL5400605 — — 1 -
CHEMBL5403818 — — 1 -
CHEMBL5418727 — — 1 -
CHEMBL5430647 — — 1 -
CHEMBL5431786 — — 1 -
CHEMBL5425904 — — 1 -
CHEMBL5423709 — — 1 -
CHEMBL5395828 — — 1 -
CHEMBL5410424 — — 1 -
CHEMBL5423855 — — 1 -
CHEMBL5424717 — — 1 -
CHEMBL5415751 — — 1 -
CHEMBL5400350 — — 1 -
CHEMBL5394803 — — 1 -
CHEMBL5416765 — — 1 -
CHEMBL5432249 — — 1 -
CHEMBL5428056 — — 1 -
CHEMBL5424588 — — 1 -
CHEMBL5417089 — — 1 -
CHEMBL5395916 — — 1 -
CHEMBL5440443 — — 1 -
CHEMBL5434371 — — 1 -
CHEMBL5417969 — — 1 -
CHEMBL5406532 — — 1 -
CHEMBL5419564 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5426748 — IC50 = 16.0 nM 7.80
CHEMBL5418293 — IC50 = 16.0 nM 7.80
CHEMBL5419700 — IC50 = 25.0 nM 7.60
CHEMBL5416167 — IC50 = 26.0 nM 7.58
CHEMBL5428079 — IC50 = 29.0 nM 7.54
CHEMBL5424717 — IC50 < 10.0 nM -
CHEMBL5419920 — IC50 < 10.0 nM -
CHEMBL5415751 — IC50 < 10.0 nM -
CHEMBL5403818 — IC50 < 10.0 nM -
CHEMBL5422155 — IC50 < 10.0 nM -
CHEMBL5410118 — IC50 < 10.0 nM -
CHEMBL4871682 — IC50 < 10.0 nM -
CHEMBL5404004 — IC50 < 10.0 nM -
CHEMBL5411311 — IC50 < 10.0 nM -
CHEMBL5401647 — IC50 < 10.0 nM -
CHEMBL5424365 — IC50 < 10.0 nM -
CHEMBL5428722 — IC50 < 10.0 nM -
CHEMBL5406857 — IC50 < 10.0 nM -
CHEMBL5413640 — IC50 - — -
CHEMBL5407498 — IC50 - — -
CHEMBL5394750 — IC50 < 10.0 nM -
CHEMBL5402339 — IC50 < 10.0 nM -
CHEMBL5407109 — IC50 < 10.0 nM -
CHEMBL5435651 — IC50 < 10.0 nM -
CHEMBL5437465 — IC50 < 10.0 nM -
CHEMBL4854181 — IC50 < 10.0 nM -
CHEMBL5416765 — IC50 < 10.0 nM -
CHEMBL5419564 — IC50 < 10.0 nM -
CHEMBL5406532 — IC50 < 10.0 nM -
CHEMBL5417969 — IC50 < 10.0 nM -
CHEMBL5434371 — IC50 < 10.0 nM -
CHEMBL5440443 — IC50 < 10.0 nM -
CHEMBL5395916 — IC50 < 10.0 nM -
CHEMBL5417089 — IC50 < 10.0 nM -
CHEMBL5424588 — IC50 < 10.0 nM -
CHEMBL5428056 — IC50 < 10.0 nM -
CHEMBL5432249 — IC50 < 10.0 nM -
CHEMBL5423855 — IC50 - — -
CHEMBL5394803 — IC50 < 10.0 nM -
CHEMBL5400350 — IC50 < 10.0 nM -
CHEMBL5400605 — IC50 < 10.0 nM -
CHEMBL5418727 — IC50 < 10.0 nM -
CHEMBL5430647 — IC50 < 10.0 nM -
CHEMBL5431786 — IC50 < 10.0 nM -
CHEMBL5425904 — IC50 < 10.0 nM -
CHEMBL5423709 — IC50 < 10.0 nM -
CHEMBL5395828 — IC50 < 10.0 nM -
CHEMBL5410424 — IC50 < 10.0 nM -