Assay Detail
Binding
CHEMBL5318938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-fused DAPK3 (1 to 320 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using MYPT1 as peptide substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Death-Associated Protein Kinases for Treatment of Human Diseases: Recent Advances and Future Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.73 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410656 | — | — | 1 | 6.92 |
| CHEMBL5413882 | — | — | 1 | 6.90 |
| CHEMBL5303531 | — | — | 1 | 6.58 |
| CHEMBL5425555 | — | — | 1 | 6.50 |
| CHEMBL5407013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410656 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL5413882 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL5303531 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL5425555 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL5407013 | — | Ki | > | 10.0 | nM | - |