Compound Detail
CHEMBL5413882
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Basic Information
| ChEMBL ID | CHEMBL5413882 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HIGNONZTHOPLMQ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
329.4
MW (Da)
1.46
ALogP
6
HBA
2
HBD
106.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Death-associated protein kinase 3 CHEMBL2468 | Ki | 6.9 | 6.9 | 126.0 | 1 |
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | Ki | 5.6 | 5.6 | 2500.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.2 | 5.2 | 6310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Death-associated protein kinase 3 | Ki | = | 126.0 | nM | 6.9 | Inhibition of human recombinant GST-fused DAPK3 (1 to 320 residues) expressed in... | 36645394 |
| Serine/threonine-protein kinase pim-3 | Ki | = | 2500.0 | nM | 5.6 | Inhibition of human full length-His6 tagged PIM3 (1 to 326 residues) expressed i... | 36645394 |
| Serine/threonine-protein kinase pim-1 | Ki | = | 6310.0 | nM | 5.2 | Inhibition of human full length-His6 tagged PIM1 (1 to 312 residues) expressed i... | 36645394 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36645394 | 10.1021/acs.jmedchem.2c01606 | Death-associated protein kinase 3 | 1 |
| 36645394 | 10.1021/acs.jmedchem.2c01606 | Serine/threonine-protein kinase pim-1 | 1 |
| 36645394 | 10.1021/acs.jmedchem.2c01606 | Serine/threonine-protein kinase pim-2 | 1 |
| 36645394 | 10.1021/acs.jmedchem.2c01606 | Serine/threonine-protein kinase pim-3 | 1 |
Data from ChEMBL 36 via Core Engine