Assay Detail
Binding
CHEMBL5319085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presence of ATP by caliper microfluidic mobility shift technology
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.09 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403330 | — | — | 1 | 8.00 |
| CHEMBL5409666 | — | — | 1 | 7.96 |
| CHEMBL5415586 | — | — | 1 | 7.75 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.68 |
| CHEMBL3622821 | UPADACITINIB | 4.0 | 1 | 7.58 |
| CHEMBL5433426 | — | — | 1 | 7.41 |
| CHEMBL5270549 | — | — | 1 | 7.23 |
| CHEMBL4297507 | DELGOCITINIB | 3.0 | 1 | 6.99 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 6.75 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 6.73 |
| CHEMBL4747591 | — | — | 1 | 5.81 |
| CHEMBL3655081 | ABROCITINIB | 4.0 | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403330 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5409666 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5415586 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3622821 | UPADACITINIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5433426 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5270549 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4297507 | DELGOCITINIB | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4747591 | — | IC50 | = | 1539.0 | nM | 5.81 |
| CHEMBL3655081 | ABROCITINIB | IC50 | = | 7073.0 | nM | 5.15 |