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Assay Detail

CHEMBL5319126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of Sporosarcina pasteurii Urease assessed as inhibition constant by Lineweaver-Burk plots analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sporosarcina pasteurii
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.
Macegoniuk K, Tabor W, Mazzei L, Cianci M, Giurg M, Olech K, Burda-Grabowska M, Kaleta R, Grabowiecka A, Mucha A, Ciurli S, Berlicki Ł.
J Med Chem (2023) 66 : 2054 -2063
PubMed 36661843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 8.56 10.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5193976 1 10.89
CHEMBL5083255 1 10.80
CHEMBL5078831 1 10.44
CHEMBL5085860 1 9.01
CHEMBL3922662 1 8.85
CHEMBL3892953 1 8.79
CHEMBL5433841 1 8.79
CHEMBL3940631 1 8.72
CHEMBL5421457 1 8.61
CHEMBL3932329 1 8.49
CHEMBL5094204 1 8.45
CHEMBL3894673 1 8.39
CHEMBL3983492 1 8.27
CHEMBL5194538 1 8.17
CHEMBL5437031 1 7.86
CHEMBL5428407 1 7.80
CHEMBL5431571 1 7.76
CHEMBL3964347 1 7.62
CHEMBL5410446 1 7.58
CHEMBL3913676 1 7.36
CHEMBL5177233 1 7.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5193976 Ki = 0.013 nM 10.89
CHEMBL5083255 Ki = 0.016 nM 10.80
CHEMBL5078831 Ki = 0.036 nM 10.44
CHEMBL5085860 Ki = 0.97 nM 9.01
CHEMBL3922662 Ki = 1.42 nM 8.85
CHEMBL3892953 Ki = 1.63 nM 8.79
CHEMBL5433841 Ki = 1.63 nM 8.79
CHEMBL3940631 Ki = 1.89 nM 8.72
CHEMBL5421457 Ki = 2.45 nM 8.61
CHEMBL3932329 Ki = 3.26 nM 8.49
CHEMBL5094204 Ki = 3.56 nM 8.45
CHEMBL3894673 Ki = 4.04 nM 8.39
CHEMBL3983492 Ki = 5.36 nM 8.27
CHEMBL5194538 Ki = 6.79 nM 8.17
CHEMBL5437031 Ki = 13.7 nM 7.86
CHEMBL5428407 Ki = 15.78 nM 7.80
CHEMBL5431571 Ki = 17.4 nM 7.76
CHEMBL3964347 Ki = 24.1 nM 7.62
CHEMBL5410446 Ki = 26.55 nM 7.58
CHEMBL3913676 Ki = 44.0 nM 7.36
CHEMBL5177233 Ki = 75.2 nM 7.12