Compound Detail
CHEMBL3940631
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Basic Information
| ChEMBL ID | CHEMBL3940631 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTJRNFGGGCLXSL-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
292.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.05
Ki 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 8.72 | 8.72 | 1.9 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.05 | 8.05 | 8.9 | 1 |
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 6.03 | 6.03 | 935.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 1.89 | nM | 8.72 | Competitive inhibition of Sporosarcina pasteurii Urease assessed as inhibition c... | 36661843 |
| Unchecked | IC50 | = | 8.86 | nM | 8.05 | Inhibition of Proteus mirabilis PCM 543 Urease in PBS buffer measured for 1.5 hr... | 36661843 |
| Methionine aminopeptidase 2 | IC50 | = | 935.0 | nM | 6.03 | Non-covalent/mixed type inhibition of recombinant human MetAP2 using Met-AMC as ... | 27692546 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36661843 | 10.1021/acs.jmedchem.2c01799 | Unchecked | 4 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Aminopeptidase N | 2 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Leucine aminopeptidase | 1 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Methionine aminopeptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine