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Assay Detail

CHEMBL5319129

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Proteus mirabilis PCM 543 Urease in PBS buffer measured for 1.5 hrs by microplate reader analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Proteus mirabilis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.
Macegoniuk K, Tabor W, Mazzei L, Cianci M, Giurg M, Olech K, Burda-Grabowska M, Kaleta R, Grabowiecka A, Mucha A, Ciurli S, Berlicki Ł.
J Med Chem (2023) 66 : 2054 -2063
PubMed 36661843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.72 8.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3983492 1 8.38
CHEMBL5085860 1 8.13
CHEMBL3940631 1 8.05
CHEMBL5074774 1 7.94
CHEMBL5193976 1 7.93
CHEMBL3931605 1 7.93
CHEMBL3964347 1 7.92
CHEMBL5437031 1 7.87
CHEMBL5078831 1 7.80
CHEMBL3913676 1 7.80
CHEMBL3922662 1 7.78
CHEMBL5083255 1 7.77
CHEMBL3932329 1 7.70
CHEMBL5410446 1 7.67
CHEMBL3892953 1 7.66
CHEMBL5431571 1 7.64
CHEMBL5421457 1 7.62
CHEMBL5428407 1 7.61
CHEMBL5094204 1 7.60
CHEMBL3930560 1 7.60
CHEMBL5194538 1 7.57
CHEMBL51085 EBSELEN 3.0 1 7.54
CHEMBL5433841 1 7.27
CHEMBL3912637 1 6.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3983492 IC50 = 4.19 nM 8.38
CHEMBL5085860 IC50 = 7.48 nM 8.13
CHEMBL3940631 IC50 = 8.86 nM 8.05
CHEMBL5074774 IC50 = 11.5 nM 7.94
CHEMBL5193976 IC50 = 11.8 nM 7.93
CHEMBL3931605 IC50 = 11.8 nM 7.93
CHEMBL3964347 IC50 = 12.1 nM 7.92
CHEMBL5437031 IC50 = 13.6 nM 7.87
CHEMBL5078831 IC50 = 16.0 nM 7.80
CHEMBL3913676 IC50 = 15.9 nM 7.80
CHEMBL3922662 IC50 = 16.8 nM 7.78
CHEMBL5083255 IC50 = 17.0 nM 7.77
CHEMBL3932329 IC50 = 20.0 nM 7.70
CHEMBL5410446 IC50 = 21.2 nM 7.67
CHEMBL3892953 IC50 = 21.9 nM 7.66
CHEMBL5431571 IC50 = 22.7 nM 7.64
CHEMBL5421457 IC50 = 23.8 nM 7.62
CHEMBL5428407 IC50 = 24.6 nM 7.61
CHEMBL5094204 IC50 = 25.0 nM 7.60
CHEMBL3930560 IC50 = 25.1 nM 7.60
CHEMBL5194538 IC50 = 26.9 nM 7.57
CHEMBL51085 EBSELEN IC50 = 29.2 nM 7.54
CHEMBL5433841 IC50 = 54.0 nM 7.27
CHEMBL3912637 IC50 = 322.0 nM 6.49