Assay Detail
Binding
CHEMBL5320177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP1-Blue ISG |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 5.07 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417158 | — | — | 1 | 6.55 |
| CHEMBL5424638 | — | — | 1 | 6.42 |
| CHEMBL5432208 | — | — | 1 | 5.64 |
| CHEMBL5414312 | — | — | 1 | 5.56 |
| CHEMBL4867353 | — | — | 1 | 5.52 |
| CHEMBL4434776 | — | — | 1 | 5.46 |
| CHEMBL5416014 | — | — | 1 | 5.45 |
| CHEMBL5396779 | — | — | 1 | 5.35 |
| CHEMBL5437805 | — | — | 1 | 5.22 |
| CHEMBL5408678 | — | — | 1 | 4.98 |
| CHEMBL5417810 | — | — | 1 | 4.94 |
| CHEMBL5419901 | — | — | 1 | 4.75 |
| CHEMBL5428811 | — | — | 1 | 4.75 |
| CHEMBL5416022 | — | — | 1 | 4.68 |
| CHEMBL5411646 | — | — | 1 | 4.67 |
| CHEMBL5397751 | — | — | 1 | 4.65 |
| CHEMBL5397964 | — | — | 1 | 4.64 |
| CHEMBL5394539 | — | — | 1 | 4.52 |
| CHEMBL5412983 | — | — | 1 | 4.49 |
| CHEMBL5437286 | — | — | 1 | 4.49 |
| CHEMBL5397564 | — | — | 1 | 4.47 |
| CHEMBL5433989 | — | — | 1 | 4.42 |
| CHEMBL5394751 | — | — | 1 | - |
| CHEMBL5420190 | — | — | 1 | - |
| CHEMBL5414917 | — | — | 1 | - |
| CHEMBL5433519 | — | — | 1 | - |
| CHEMBL5435779 | — | — | 1 | - |
| CHEMBL5435332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417158 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5424638 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5432208 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5414312 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4867353 | — | EC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4434776 | — | EC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL5416014 | — | EC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5396779 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5437805 | — | EC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL5408678 | — | EC50 | = | 10490.0 | nM | 4.98 |
| CHEMBL5417810 | — | EC50 | = | 11490.0 | nM | 4.94 |
| CHEMBL5419901 | — | EC50 | = | 17860.0 | nM | 4.75 |
| CHEMBL5428811 | — | EC50 | = | 17580.0 | nM | 4.75 |
| CHEMBL5416022 | — | EC50 | = | 20640.0 | nM | 4.68 |
| CHEMBL5411646 | — | EC50 | = | 21330.0 | nM | 4.67 |
| CHEMBL5397751 | — | EC50 | = | 22320.0 | nM | 4.65 |
| CHEMBL5397964 | — | EC50 | = | 22770.0 | nM | 4.64 |
| CHEMBL5394539 | — | EC50 | = | 29930.0 | nM | 4.52 |
| CHEMBL5412983 | — | EC50 | = | 32720.0 | nM | 4.49 |
| CHEMBL5437286 | — | EC50 | = | 32280.0 | nM | 4.49 |
| CHEMBL5397564 | — | EC50 | = | 33640.0 | nM | 4.47 |
| CHEMBL5433989 | — | EC50 | = | 37990.0 | nM | 4.42 |
| CHEMBL5394751 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5420190 | — | EC50 | = | 1938000.0 | nM | - |
| CHEMBL5414917 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5433519 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5435779 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5435332 | — | EC50 | > | 100000.0 | nM | - |