Compound Detail
CHEMBL5428811
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Basic Information
| ChEMBL ID | CHEMBL5428811 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AUPXAWWZHMSCJS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
362.3
MW (Da)
2.83
ALogP
6
HBA
2
HBD
105.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Stimulator of interferon genes protein CHEMBL4523377 | EC50 | 4.75 | 4.75 | 17580.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Stimulator of interferon genes protein | EC50 | = | 17580.0 | nM | 4.75 | Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hr... | 36808996 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36808996 | 10.1021/acs.jmedchem.2c01714 | Stimulator of interferon genes protein | 2 |
Data from ChEMBL 36 via Core Engine