Assay Detail
Functional
CHEMBL5320301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in parasitemia incubated for 72 hrs by LDH assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.63 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399238 | — | — | 1 | 8.72 |
| CHEMBL5395617 | — | — | 1 | 8.10 |
| CHEMBL5436150 | — | — | 1 | 7.82 |
| CHEMBL5427940 | — | — | 1 | 7.82 |
| CHEMBL5403669 | — | — | 1 | 7.78 |
| CHEMBL5408296 | — | — | 1 | 7.27 |
| CHEMBL5396856 | — | — | 1 | 7.20 |
| CHEMBL5418901 | — | — | 1 | 7.20 |
| CHEMBL5416583 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399238 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5395617 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5436150 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5427940 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5403669 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5408296 | — | EC50 | = | 53.9 | nM | 7.27 |
| CHEMBL5396856 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5418901 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5416583 | — | EC50 | = | 171.0 | nM | 6.77 |