Compound Detail
CHEMBL5408296
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Basic Information
| ChEMBL ID | CHEMBL5408296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXHVMTZWSKDPRR-UHFFFAOYSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.9
MW (Da)
5.30
ALogP
5
HBA
1
HBD
64.7
PSA (Ų)
0.46
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 7.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 7.27 | 7.052 | 53.9 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | EC50 | = | 53.9 | nM | 7.27 | Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in... | 36812492 |
| Plasmodium falciparum | EC50 | = | 78.9 | nM | 7.1 | Antimalarial activity against N-(3-Fluoropheny1)-8-methoxy-4-methy1-1,5-dioxo-2,... | 36812492 |
| Plasmodium falciparum | EC50 | = | 85.0 | nM | 7.07 | Antimalarial activity against asexual stage drug-resistant Plasmodium falciparum... | 36812492 |
| Plasmodium falciparum | EC50 | = | 112.0 | nM | 6.95 | Antimalarial activity against N-(3-Fluoropheny1)-8-methoxy-4-methy1-1,5-dioxo-2,... | 36812492 |
| Plasmodium falciparum | EC50 | = | 136.0 | nM | 6.87 | Antimalarial activity against N-(3-Fluoropheny1)-8-methoxy-4-methy1-1,5-dioxo-2,... | 36812492 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36812492 | 10.1021/acs.jmedchem.2c02092 | Plasmodium falciparum | 6 |
| 36812492 | 10.1021/acs.jmedchem.2c02092 | Unchecked | 3 |
Data from ChEMBL 36 via Core Engine