Assay Detail
Functional
CHEMBL5320304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against N-(3-Fluoropheny1)-8-methoxy-4-methy1-1,5-dioxo-2,3-dihydropyrrolo(1,2-alquinazoline-3a-carboxamide-resistant Plasmodium falciparum Dd2 B2 harboring D425E single nucleotide polymorphism in ATP4 assessed as reduction in parasitemia incubated for 72 hrs by LDH assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.61 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399238 | — | — | 1 | 8.68 |
| CHEMBL5436150 | — | — | 1 | 7.52 |
| CHEMBL5403669 | — | — | 1 | 7.40 |
| CHEMBL5395617 | — | — | 1 | 7.37 |
| CHEMBL5408296 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399238 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5436150 | — | EC50 | = | 30.1 | nM | 7.52 |
| CHEMBL5403669 | — | EC50 | = | 39.6 | nM | 7.40 |
| CHEMBL5395617 | — | EC50 | = | 42.8 | nM | 7.37 |
| CHEMBL5408296 | — | EC50 | = | 78.9 | nM | 7.10 |