Assay Detail
Functional
CHEMBL5320305
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Antimalarial activity against asexual stage drug-resistant Plasmodium falciparum Dd2 expressing ATP4 ATPase 1398F/P990R/D1247Y mutant assessed as reduction in parasitemia incubated for 72 hrs by LDH assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.63 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399238 | — | — | 1 | 8.05 |
| CHEMBL5408296 | — | — | 1 | 7.07 |
| CHEMBL5395617 | — | — | 1 | 6.87 |
| CHEMBL5436150 | — | — | 1 | 6.85 |
| CHEMBL5427940 | — | — | 1 | 6.76 |
| CHEMBL5396856 | — | — | 1 | 6.03 |
| CHEMBL5418901 | — | — | 1 | 5.84 |
| CHEMBL5416583 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399238 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5408296 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5395617 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5436150 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5427940 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5396856 | — | EC50 | = | 934.0 | nM | 6.03 |
| CHEMBL5418901 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5416583 | — | EC50 | = | 2860.0 | nM | 5.54 |